Tungsten in PDB 6drb: Crystal Structure of the Yoph PTP1B Wpd Loop Chimera 3 Ptpase Bound to Tungstate

The structure of Crystal Structure of the Yoph PTP1B Wpd Loop Chimera 3 Ptpase Bound to Tungstate, PDB code: 6drb was solved by Y.Morales, S.J.Johnson, A.C.Hengge, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	36.87 / 2.75
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	49.743, 54.920, 97.848, 90.00, 90.00, 90.00
R / Rfree (%)	21.3 / 26.4

The binding sites of Tungsten atom in the Crystal Structure of the Yoph PTP1B Wpd Loop Chimera 3 Ptpase Bound to Tungstate (pdb code 6drb). This binding sites where shown within 5.0 Angstroms radius around Tungsten atom.
In total only one binding site of Tungsten was determined in the Crystal Structure of the Yoph PTP1B Wpd Loop Chimera 3 Ptpase Bound to Tungstate, PDB code: 6drb:

Tungsten binding site 1 out of 1 in the Crystal Structure of the Yoph PTP1B Wpd Loop Chimera 3 Ptpase Bound to Tungstate


Mono view


Stereo pair view

A full contact list of Tungsten with other atoms in the W binding site number 1 of Crystal Structure of the Yoph PTP1B Wpd Loop Chimera 3 Ptpase Bound to Tungstate within 5.0Å range: probe atom residue distance (Å) B Occ A:W501 b:0.5 occ:1.00 W A:WO4501 0.0 0.5 1.0 O1 A:WO4501 1.9 0.4 1.0 O3 A:WO4501 1.9 0.2 1.0 O2 A:WO4501 1.9 0.6 1.0 O4 A:WO4501 1.9 0.2 1.0 SG A:CYS403 3.2 77.9 1.0 CA A:GLY408 3.9 63.3 1.0 N A:GLY408 3.9 74.4 1.0 N A:ARG409 4.1 61.4 1.0 N A:ALA405 4.1 55.6 1.0 NZ A:LYS447 4.1 93.2 1.0 CB A:ALA405 4.4 56.4 1.0 N A:ARG404 4.5 75.2 1.0 C A:GLY408 4.5 63.1 1.0 CB A:CYS403 4.5 79.9 1.0 CB A:ARG404 4.5 83.4 1.0 N A:GLY406 4.6 55.0 1.0 NE A:ARG409 4.7 94.1 1.0 CA A:ALA405 4.8 56.8 1.0 CZ A:ARG409 4.8 98.0 1.0 CG A:ARG409 4.8 66.8 1.0 OE1 A:GLN446 4.9 77.3 1.0 N A:VAL407 4.9 69.2 1.0 CA A:ARG404 4.9 77.1 1.0 CD A:ARG409 5.0 69.2 1.0 C A:ARG404 5.0 76.1 1.0

G.Moise, Y.Morales, V.Beaumont, T.Caradonna, J.P.Loria, S.J.Johnson, A.C.Hengge. A Yoph PTP1B Chimera Shows the Importance of the Wpd-Loop Sequence to the Activity, Structure, and Dynamics of Protein Tyrosine Phosphatases. Biochemistry V. 57 5315 2018.
ISSN: ISSN 1520-4995
PubMed: 30110154
DOI: 10.1021/ACS.BIOCHEM.8B00663